New study links Alzheimer's disease to DNA changes in brain cells
最新研究顯示阿茲海默症與腦細胞的 DNA 變化有關
更新於: 2026年9月14日 上午03:00
For decades, scientists viewed Alzheimer's disease primarily as a result of protein tangles and plaques clogging the brain.
數十年來，科學家將阿茲海默症視為大腦中蛋白質纏結與斑塊堆積所致。
However, groundbreaking new research suggests the truth lies deeper: within the very structure of our DNA.
然而，突破性的新研究顯示真相更為深層：存在於我們DNA的結構之中。
A recent study reveals that Alzheimer's is fundamentally linked to genomic instability—a state where the DNA inside brain cells becomes damaged and disorganized.
近期的研究揭示，阿茲海默症與基因組不穩定性（即腦細胞內的DNA受損且混亂的狀態）有根本性的連結。
These include somatic mutations caused by oxidative stress, structural rearrangements that disrupt gene expression, and epigenetic shifts that alter how brain cells function.
這些變化包括由氧化壓力引起的體細胞突變、擾亂基因表現的結構重組，以及改變腦細胞功能的表觀遺傳轉變。
Even the brain's immune cells, the microglia, show signs of damage, creating a cycle of inflammation that further degrades neuronal health.
甚至大腦的免疫細胞——微膠細胞，也顯現出受損跡象，引發了一場進一步降低神經元健康的發炎循環。
Importantly, this damage is compounded by the brain’s failing repair mechanisms.
重要的是，這種損害因大腦修復機制的失效而加劇。
By moving beyond traditional views, researchers are now looking toward new therapeutic targets, such as supporting oligodendrocyte health and stabilizing the genome, offering fresh hope for treatments that could address the root causes of this complex disease.
透過超越傳統觀點，研究人員現在正尋找新的治療標靶，例如支持少突膠質細胞的健康並穩定基因組，為解決這種複雜疾病的根源提供了治療上的新希望。
