科學家逆轉小鼠與年齡相關的視力喪失
Scientists Reverse Age-Related Vision Loss in Mice
哈佛醫學院的科學家們在再生醫學領域取得了重大突破，成功逆轉了小鼠的視力喪失。
Scientists at Harvard Medical School have achieved a breakthrough in regenerative medicine, successfully reversing vision loss in mice.
這項研究於2020年發表在《自然》(Nature)雜誌上，其提出衰老如同一座時鐘，是可以撥回的。
Published in the journal Nature in 2020, this study proposes that aging is like a clock that can be turned back.
隨著細胞老化，會積累表觀遺傳噪音（或稱化學鏽蝕），這種噪音會阻礙細胞正確解讀遺傳指令。
As cells age, they accumulate epigenetic noise, or chemical rust, which prevents them from reading their genetic instructions correctly.
由大衛·辛克萊(David Sinclair)領導的團隊，利用名為OSK的特定遺傳雞尾酒配方—Oct4、Sox2與Klf4—成功地將這些細胞重置為更年輕的狀態。
The team, led by David Sinclair, used a specific genetic cocktail known as OSK—Oct4, Sox2, and Klf4—to effectively reset these cells to a more youthful state.
研究人員通過病毒載體遞送此治療方式，成功恢復了老年小鼠的視力，甚至逆轉了由青光眼導致的視力喪失。
By delivering this treatment via a viral vector, the researchers successfully restored sight in aged mice and even reversed vision loss caused by glaucoma.
此外，該治療還刺激了視神經的再生。
Furthermore, the treatment stimulated optic nerve regeneration.
雖然專家提醒人體臨床試驗仍遙不可及，但該研究為未來逆轉衰老引起的損傷提供了希望的曙光。
While experts caution that human clinical trials are still far off, this study provides a promising glimpse into a future where age-related damage might be reversible.
科學通過針對衰老的根本驅動因素，正在為保持人類健康與長壽邁出重要的一步。
By targeting the fundamental drivers of aging, science is taking a significant step toward preserving our health and longevity.
